The Apoptosis
My articles | All cells are mortal. They're designed to die at some time. This mechanism allows one's body to maintain homeostasis. The existing cells die to allow for the spreading of younger cells. When cells experience toxic substances, they trigger their suicide button to retain the toxin. The whole process of programmed cell death is known as apoptosis. Here is the result of studies in Cancer Translational Research.
This really is one treatment method discovered in cancer translational research, a discipline integrating laboratory and clinical findings to deliver solutions, such as diagnostic treatment, safe and effective treatment and prevention strategy, towards the public health threat - cancer. Each time a normal body cell continues splitting and multiply throughout the body thereby triggering physiologic distress, they're called cancer cells. The thought of apoptosis as being a management of cancer is founded on the supposition that cancer cells could possibly be programmed to die while using the apoptotic pathway.
Apoptosis and chemotherapy
It had been found out that chemotherapeutic drugs work by either inducing apoptosis or causing direct injury to the cellular structure. Thus, one can argue that apoptosis being a treatment solutions are similar in results since the active chemotherapy. What benefits than does the apoptosis cancer translational research offer?
Apoptotic research is not useless in anyway. Inhibition of anti-apoptotic proteins, Bcl-2 family and IAPs is discovered to function in killing cancer cells in animal models. Chemical agents, though don't cause direct cell death, put together to bar an upstream pathway of apoptosis. These are Herceptin for breast cancer, Iressa for united states, and Gleevec for CML. All these agents will be in the trial stage. A promising treatment technique for non-Hodgkin's lymphoma is Rituximab, an antibody directed for the B cell antigen B220 with the cancer cells.
Projected mechanism of action of Rituximab may be the induction of apoptosis. A protein called p-53 is discovered to induce apoptosis. A chemical agent MDM2 is discovered to activate p-53 thereby arrests cell cycle and initiate cell death. Scientists may also be investigating a treatment strategy combining chemotherapy and apoptosis. They debate that this course is much more likely to be curative. Another proposed strategy involving apoptosis is eliminating a nutrient source of cancer cells by killing the veins supplying them. This strategy was discovered to function in animal models concerning the protein tumor necrosis factor (TNF).
The apoptotic mechanism gives a productive strategy in cancer translational research. Rapid progress in apoptosis as well as the novel agents is cause for optimism.
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By Terry R Dancer
Article Source: EzineArticles.com
